The Ghost opens with a raid: Interpol officers Priya (Sonal Chauhan) and Vikram (Akkineni Nagarjuna) take out a group of smugglers somewhere in the high desertlands of East Arabia. After a volley of bullets wipes out the entire gang, Vikram and Priya, still in full tactical gear, turn towards each other and passionately kiss. These are the sort of tone-deaf theatrics that turn director Praveen Sattaru's crime thriller into a forgettable dud.
Soon after this raid, Vikram and his girlfriend-cum-partner Priya respond to a hostage situation that goes horribly wrong, marking the end ....